Significance of Plasmodium berghei Amino Acid Transporter 1 in Food Vacuole Functionality and Its Association with Cerebral Pathogenesis-Reference-Cited by-同舟云学术

Significance of Plasmodium berghei Amino Acid Transporter 1 in Food Vacuole Functionality and Its Association with Cerebral Pathogenesis

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Anand Aditya¹²,Chandana Manjunatha¹³,Ghosh Sourav¹²,Das Rahul¹²,Singh Nalini¹,Vaishalli Pradeep Mini¹²,Gantasala Nagavara Prasad⁴,Padmanaban Govindarajan⁵,Nagaraj Viswanathan Arun¹^ORCID

Affiliation:

1. Infectious Disease Biology, Institute of Life Sciences, Bhubaneswar, Odisha, India

2. Regional Centre for Biotechnology, Faridabad, Haryana, India

3. School of Biotechnology, Kalinga Institute of Industrial Technology, Bhubaneswar, Odisha, India

4. Advanced Technology Platform Centre, Regional Centre for Biotechnology, Faridabad, Haryana, India

5. Department of Biochemistry, Indian Institute of Science, Bangalore, Karnataka, India

Abstract

Food vacuoles of the malaria parasite are involved in the degradation of red blood cell hemoglobin. The amino acids derived from hemoglobin degradation support parasite growth, and the heme released is detoxified into hemozoin.

Funder

Science and Engineering Research Board (SERB), Department of Science and Technology, Ministry of Science and Technology, India

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04943-22

Reference72 articles.

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3. Malaria in 2022: Increasing challenges, cautious optimism

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5. Excess hemoglobin digestion and the osmotic stability ofPlasmodium falciparum–infected red blood cells

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