Sensitivity and Specificity of SARS-CoV-2 Rapid Antigen Detection Tests Using Oral, Anterior Nasal, and Nasopharyngeal Swabs: a Diagnostic Accuracy Study

Author:

Wölfl-Duchek Michael1,Bergmann Felix12,Jorda Anselm1,Weber Maria1,Müller Matthias13,Seitz Tamara4,Zoufaly Alexander45,Strassl Robert6,Zeitlinger Markus1ORCID,Herkner Harald3,Schnidar Harald7,Anderle Karolina1,Derhaschnig Ulla1

Affiliation:

1. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

2. Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria

3. Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria

4. Fourth Medical Department for Infectious Diseases and Tropical Medicine, Clinic Favoriten, Vienna, Austria

5. Faculty of Medicine, Sigmund Freud University, Vienna, Austria

6. Department of Laboratory Medicine, Division of Clinical Virology, Medical University of Vienna, Vienna, Austria

7. Scarletred Holding GmbH, Vienna, Austria

Abstract

Rapid antigen detection devices for SARS-CoV-2 represent a valuable tool for monitoring the spread of infection. However, the reliability of the tests depends largely on the test performance and the respective sampling method.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference30 articles.

1. Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection;Dinnes J;Cochrane Database Syst Rev,2021

2. Accuracy and cost description of rapid antigen test compared with reverse transcriptase-polymerase chain reaction for SARS-CoV-2 detection;Jakobsen KK;Dan Med J,2021

3. Sensitivity of Rapid Antigen Testing and RT-PCR Performed on Nasopharyngeal Swabs versus Saliva Samples in COVID-19 Hospitalized Patients: Results of a Prospective Comparative Trial (RESTART)

4. Complications of nasal and pharyngeal swabs: a relevant challenge of the COVID-19 pandemic?

5. Assessment of Sensitivity and Specificity of Patient-Collected Lower Nasal Specimens for Severe Acute Respiratory Syndrome Coronavirus 2 Testing

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