A Single Residue within the MCR-1 Protein Confers Anticipatory Resilience-Reference-Cited by-同舟云学术

A Single Residue within the MCR-1 Protein Confers Anticipatory Resilience

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Frantz Renate¹²,Gwozdzinski Konrad¹²,Gisch Nicolas³^ORCID,Doijad Swapnil Prakash¹²^ORCID,Hudel Martina¹,Wille Maria⁴,Abu Mraheil Mobarak¹,Schwudke Dominik³⁵⁶^ORCID,Imirzalioglu Can¹⁷²,Falgenhauer Linda⁴⁷²,Ehrmann Michael⁸⁹,Chakraborty Trinad¹⁷²^ORCID

Affiliation:

1. Institute of Medical Microbiology, Justus Liebig University Giessen, Giessen, Germany

2. German Center for Infection Research, Partner Site: Giessen-Marburg-Langen, Giessen, Germany

3. Division of Bioanalytical Chemistry, Priority Area Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany

4. Institute of Hygiene and Environmental Medicine, Justus Liebig University Giessen, Giessen, Germany

5. German Center for Infection Research, Partner Site: Hamburg-Lübeck-Borstel-Riems, Borstel, Germany

6. Airway Research Center North, Partner Site: Research Center Borstel, Borstel, Germany

7. Hessian University Competence Center for Hospital Hygiene, Justus Liebig University Giessen, Giessen, Germany

8. Center of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany

9. School of Biosciences, Cardiff University, Cardiff, United Kingdom

Abstract

The global presence of transferable mcr genes in a wide range of Gram-negative bacteria from clinical, veterinary, food, and aquaculture environments is disconcerting. Its success as a transmissible resistance factor remains enigmatic, because its expression imposes fitness costs and imparts only moderate levels of colistin resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03592-22

Reference65 articles.

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