<i>In Vivo</i> Genome-Wide Gene Expression Profiling Reveals That <i>Haemophilus influenzae</i> Purine Synthesis Pathway Benefits Its Infectivity within the Airways-Reference-Cited by-同舟云学术

In Vivo Genome-Wide Gene Expression Profiling Reveals That Haemophilus influenzae Purine Synthesis Pathway Benefits Its Infectivity within the Airways

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Euba Begoña¹,Gil-Campillo Celia¹²,Asensio-López Javier¹³,López-López Nahikari¹²,Sen-Kilic Emel⁴⁵,Díez-Martínez Roberto⁶,Burgui Saioa³,Barbier Mariette⁴⁵^ORCID,Garmendia Junkal¹²⁷^ORCID

Affiliation:

1. Instituto de Agrobiotecnología (IDAB), Consejo Superior de Investigaciones Científicas (CSIC)-Gobierno de Navarra, Mutilva, Spain

2. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain

3. Asociación de la Industria Navarra (AIN)-Gobierno de Navarra, Cordovilla, Spain

4. Vaccine Development Center, West Virginia University Health Sciences Center, Morgantown, West Virginia, USA

5. Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Morgantown, West Virginia, USA

6. Telum Therapeutics, Noain, Spain

7. Conexión Nanomedicina-CSIC, Madrid, Spain

Abstract

In vivo -omic strategies offer great opportunities for increased understanding of host-pathogen interplay and for identification of therapeutic targets. Here, using transcriptome sequencing, we profiled host and pathogen gene expression during H. influenzae infection within the murine airways.

Funder

Gobierno de Navarra

Ministerio de Ciencia e Innovación

Sociedad Española de Neumología y Cirugía Torácica

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00823-23

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