A Small-Molecule Inhibitor of the Anthranilyl-CoA Synthetase PqsA for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

A Small-Molecule Inhibitor of the Anthranilyl-CoA Synthetase PqsA for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Chen Jianwei¹,Lu Yaojia¹,Ye Fei²,Zhang Hongfang¹,Zhou Yonglie³,Li Jiangtao⁴,Wu Qiang⁵,Xu Xuewei⁶,Wu Qihao¹,Wei Bin¹,Zhang Huawei¹,Wang Hong¹^ORCID

Affiliation:

1. College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China

2. College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, China

3. Zhejiang Provincial People’s Hospital, Hangzhou, China

4. The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China

5. State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China

6. Second Institute of Oceanography, MNR, Hangzhou, China

Abstract

Pseudomonas aeruginosa is a dominant hospital-acquired bacterial pathogen typically found in immunocompromised individuals. It is particularly dangerous for patients with chronic lung diseases and was identified as a serious threat for patients in the 2019 Antimicrobial Resistance Threats report ( https://www.cdc.gov/drugresistance/biggest-threats.html ).

Funder

National Natural Science Foundation of China

MOST | National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02764-21

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