A Rapid Screening Assay for Clarithromycin-Resistant Mycobacterium avium Complex Using Melting Curve Analysis with Nonfluorescent Labeled Probes-Reference-Cited by-同舟云学术

A Rapid Screening Assay for Clarithromycin-Resistant Mycobacterium avium Complex Using Melting Curve Analysis with Nonfluorescent Labeled Probes

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Aoki Akira¹,Jinno Hideto¹^ORCID,Ogawa Kenji²,Nakagawa Taku²,Inagaki Takayuki³,Wajima Takeaki⁴^ORCID,Okamoto Yoshinori¹^ORCID,Uchiya Kei-ichi⁴^ORCID

Affiliation:

1. Department of Hygienic Chemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan

2. Department of Respiratory Medicine, National Hospital Organization, Higashinagoya National Hospital, Nagoya, Japan

3. Division of Pharmaceutical Sciences I, Faculty of Pharmacy, Meijo University, Nagoya, Japan

4. Department of Microbiology, Faculty of Pharmacy, Meijo University, Nagoya, Japan

Abstract

Since macrolide antibiotics such as clarithromycin or azithromycin are key drugs in multidrug therapy for Mycobacterium avium complex (MAC) lung diseases, the rapid detection of macrolide-resistant MAC strains has important implications for the treatment of MAC. Previous studies have reported a correlation between drug susceptibility testing and the mutation of macrolide resistance genes.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04326-22

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