Mycoplasma genitalium Protein of Adhesion Suppresses T Cell Activation via CypA-CaN-NFAT Pathway

Author:

Luo Dan1234,Luo Haodang1234,Yan Xiaoliang123,Lei Aihua123,He Jun4,Liao Yating123,Peng Kailan123,Li Xia123,Ye Youyuan123,Chen Li123,Zeng Zhuo123,Xiao Hua123,Zeng Yanhua123ORCID

Affiliation:

1. Institute of Pathogenic Biology, Basic Medical School, Hengyang Medical School, University of South China, Hengyang, Hunan, China

2. Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang, Hunan, China

3. Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, Hunan, China

4. Department of Clinical Laboratory, the Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China

Abstract

Mycoplasma genitalium is a sexually transmitted bacterium that can co-infect with other infections and causes nongonococcal urethritis in males, cervicitis, pelvic inflammatory disease, premature birth, and ectopic pregnancy in women. The adhesion protein of M. genitalium (MgPa) is the primary virulence factor in the complicated pathogenicity of M. genitalium .

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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