Widespread Dissemination of Plasmid-Mediated Tigecycline Resistance Gene <i>tet</i> (X4) in <i>Enterobacterales</i> of Porcine Origin-Reference-Cited by-同舟云学术

Widespread Dissemination of Plasmid-Mediated Tigecycline Resistance Gene tet (X4) in Enterobacterales of Porcine Origin

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Wang Qin¹²,Lei Changwei¹²,Cheng Hansen¹,Yang Xue¹²,Huang Zheren¹²,Chen Xuan¹²,Ju Zijing¹²,Zhang Haoyu¹²,Wang Hongning¹²^ORCID

Affiliation:

1. Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, Sichuan Province, People’s Republic of China

2. Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, People’s Republic of China

Abstract

Tigecycline is considered to be the last resort of defense against diseases caused by broad-spectrum resistant Gram-negative bacteria. In this study, we systematically analyzed the prevalence and genetic environments of the resistance gene tet (X4) in a pig slaughterhouse and farms and the evolutionary relationship of 533 tet (X4)-positive Escherichia coli strains, including 509 tet (X4)-positive E. coli strains selected from the 27,802 assembled genomes of E. coli from the NCBI between 2002 and 2022.

Funder

National Natural Science Foundation of China

Sichuan Science and Technology Program

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01615-22

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