Combining Genome Surveillance and Metadata To Characterize the Diversity of Staphylococcus aureus Circulating in an Italian Hospital over a 9-Year Period

Author:

Postiglione U.1,Batisti Biffignandi G.1,Corbella M.2,Merla C.2,Olivieri E.3,Petazzoni G.2,Feil E. J.4,Bandi C.5,Cambieri P.2,Gaiarsa S.2ORCID,Brilli M.5,Sassera D.16ORCID

Affiliation:

1. Department of Biology and Biotechnology, University of Pavia, Pavia, Italy

2. Microbiology and Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

3. Istituto Zooproflattico Sperimentale della Lombardia e dell’Emilia Romagna, Pavia, Italy

4. The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

5. Department of Bioscience, University of Milan, Milan, Italy

6. Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

Abstract

Genome sequencing is an important tool in clinical microbiology, as it allows in-depth characterization of isolates of interest and can propel genome-based surveillance studies. Such studies can benefit from ad hoc methods of sample selection to capture the genomic diversity present in a data set.

Funder

Italian Ministry of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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