The Histone Variant H2A.Z C-Terminal Domain Has Locus-Specific Differential Effects on H2A.Z Occupancy and Nucleosome Localization-Reference-Cited by-同舟云学术

The Histone Variant H2A.Z C-Terminal Domain Has Locus-Specific Differential Effects on H2A.Z Occupancy and Nucleosome Localization

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Neumann Hannah¹,Jeronimo Celia²,Lucier Jean-François¹³,Pasquier Emeline⁴,Robert François²⁵,Wellinger Raymund J.⁴,Gaudreau Luc¹^ORCID

Affiliation:

1. Department of Biology, Université de Sherbrooke, Sherbrooke, Quebec, Canada

2. Montreal Clinical Research Institute, Montréal, Quebec, Canada

3. Center for Computational Science, Université de Sherbrooke, Sherbrooke, Quebec, Canada

4. Department of Microbiology and Infectious Diseases, Université de Sherbrooke, Sherbrooke, Quebec, Canada

5. Department of Medicine, Université de Montréal, Montréal, Quebec, Canada

Abstract

We provide evidence that the Saccharomyces cerevisiae C-terminal region of histone variant H2A.Z can mediate its special function in performing gene regulation by interacting with effector proteins and chaperones. These functional interactions allow H2A.Z not only to incorporate to very specific gene regulatory regions, but also to facilitate the gene expression process.

Funder

Canadian HIV Trials Network, Canadian Institutes of Health Research

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02550-22

Reference64 articles.

1. Histone variants on the move: substrates for chromatin dynamics

2. Histone H2A.Z Is Widely but Nonrandomly Distributed in Chromosomes of Drosophila melanogaster

3. A Histone Variant, Htz1p, and a Sir1p-like Protein, Esc2p, Mediate Silencing at HMR

4. Histone H2A.Z Regulates Transcription and Is Partially Redundant with Nucleosome Remodeling Complexes

5. H2A.Z Is Required for Global Chromatin Integrity and for Recruitment of RNA Polymerase II under Specific Conditions