BopN is a Gatekeeper of the <i>Bordetella</i> Type III Secretion System-Reference-Cited by-同舟云学术

BopN is a Gatekeeper of the Bordetella Type III Secretion System

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Navarrete Kevin Munoz¹,Bumba Ladislav²^ORCID,Prudnikova Tatyana³,Malcova Ivana¹,Allsop Tania Romero¹,Sebo Peter²^ORCID,Kamanova Jana¹^ORCID

Affiliation:

1. Laboratory of Infection Biology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic

2. Laboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic

3. Faculty of Science, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic

Abstract

The T3SS is utilized by many Gram-negative bacteria to deliver effector proteins from bacterial cytosol directly into infected host cell cytoplasm in a regulated and targeted manner. Pathogenic bordetellae use the T3SS to inject the BteA and BopN proteins into infected cells and upregulate the production of the anti-inflammatory cytokine interleukin-10 (IL-10) to evade host immunity.

Funder

Akademie Věd České Republiky

CAS | Mikrobiologický Ústav, Akademie Věd České Republiky

Grantová Agentura České Republiky

Ministerstvo Školství, Mládeže a Tělovýchovy

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04112-22

Reference75 articles.