Evolution of Multiple Domains of the HIV-1 Envelope Glycoprotein during Coreceptor Switch with CCR5 Antagonist Therapy-Reference-Cited by-同舟云学术

Evolution of Multiple Domains of the HIV-1 Envelope Glycoprotein during Coreceptor Switch with CCR5 Antagonist Therapy

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Du Yueqi¹,Wu Ellen¹,Gao Xiang¹,Zhang Jie¹,Martin John C.²,Rosa Bruce A.²,Mitreva Makedonka²³,Ratner Lee¹^ORCID

Affiliation:

1. Division of Oncology, Washington University School of Medicine, St. Louis, Missouri, USA

2. Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, USA

3. McDonnell Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA

Abstract

This study is novel in combining single-genome sequence analysis and next-generation sequencing to characterize HIV-1 quasispecies. The work highlights the importance of mutants present at frequencies of 1% or less in development of drug resistance. This study highlights a critical role of specific amino acid substitutions outside V3 that contribute to coreceptor shift as well as important roles of the V1/V2, V4, C3, and C4 domain residues.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00725-22

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