Detection of Circulating HPV16 DNA as a Biomarker for Cervical Cancer by a Bead-Based HPV Genotyping Assay-Reference-Cited by-同舟云学术

Detection of Circulating HPV16 DNA as a Biomarker for Cervical Cancer by a Bead-Based HPV Genotyping Assay

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Galati Luisa¹,Combes Jean-Damien¹,Le Calvez-Kelm Florence¹,McKay-Chopin Sandrine¹,Forey Nathalie¹,Ratel Mathis¹,McKay James¹,Waterboer Tim²,Schroeder Lea²,Clifford Gary¹,Tommasino Massimo¹^ORCID,Gheit Tarik¹^ORCID

Affiliation:

1. International Agency for Research on Cancer, Lyon, France

2. Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Abstract

The validity of HPV ctDNA as a marker of HPV-driven cancers has been previously reported. Herein we validated an alternative to ddPCR for HPV16 ctDNA detection, using a bead-based HPV genotyping assay that offers the potential advantage of reducing the cost of clinical management due to the multiplex capability of the test, thus facilitating its use in clinical settings.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01480-21

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