Clonal Complex 12 Serotype Ib Streptococcus agalactiae Strain Causing Complicated Sepsis in Neonates: Clinical Features and Genetic Characteristics

Author:

Hsu Jen-Fu12,Chen Yu-Ning12,Chu Shih-Ming12,Lee Wei-Ju12,Huang Hsuan-Rong12,Chiang Ming-Chou12,Yang Peng-Hong12,Tsai Ming-Horng23ORCID,Lu Jang-Jih245ORCID

Affiliation:

1. Division of Pediatric Neonatology, Department of Pediatrics, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan

2. School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan

3. Division of Neonatology and Pediatric Hematology and Oncology, Department of Pediatrics, Yunlin Linkou Chang Gung Memorial Hospital, Yunlin, Taiwan

4. Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan

5. Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan

Abstract

A type Ib ST12 GBS strain is not a common isolate in neonatal invasive diseases and has been ignored for a long time. However, the recent literature and our data showed that such a GBS strain is associated with a significantly higher risk of severe sepsis, higher illness severity, and a significantly higher rate of sepsis-attributable mortality.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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