Long-Term and Low-Level Envelope C2V3 Stimulation by Highly Diverse Virus Isolates Leads to Frequent Development of Broad and Elite Antibody Neutralization in HIV-1-Infected Individuals-Reference-Cited by-同舟云学术

Long-Term and Low-Level Envelope C2V3 Stimulation by Highly Diverse Virus Isolates Leads to Frequent Development of Broad and Elite Antibody Neutralization in HIV-1-Infected Individuals

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Martin Francisco¹,Marcelino José Maria¹²,Palladino Claudia¹^ORCID,Bártolo Inês¹,Tracana Susana¹,Moranguinho Inês¹,Gonçalves Paloma¹,Mateus Rita¹,Calado Rita¹,Borrego Pedro¹,Leitner Thomas³,Clemente Sofia⁴,Taveira Nuno¹²^ORCID

Affiliation:

1. Research Institute for Medicine, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal

2. Centro de Investigação Interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, Caparica, Portugal

3. Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, USA

4. Hospital da Divina Providência, Luanda, Angola

Abstract

Studies on neutralization by antibodies and their determinants in HIV-1-infected individuals have mostly been conducted in relatively recent epidemics caused by subtype B and C viruses. Results have suggested that elicitation of broadly neutralizing antibodies (bNAbs) is uncommon.

Funder

ADEIM-FFUL, Portugal

MEC | Fundação para a Ciência e a Tecnologia

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01634-22

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