Detecting KPC-2 and NDM-1 Coexpression in Klebsiella pneumoniae Complex from Human and Animal Hosts in South America-Reference-Cited by-同舟云学术

Detecting KPC-2 and NDM-1 Coexpression in Klebsiella pneumoniae Complex from Human and Animal Hosts in South America

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Vásquez-Ponce Felipe¹^ORCID,Dantas Karine¹,Becerra Johana¹,Melocco Gregory²,Esposito Fernanda²,Cardoso Brenda¹,Rodrigues Larissa¹,Lima Keila²,de Lima Aline V.²,Sellera Fábio P.³⁴,Mattos Renata⁵,Trevisoli Lucas⁵,Vianello Marco A.⁶,Sincero Thais⁷,Di Conza Jose⁸,Vespero Eliana⁹,Gutkind Gabriel⁸^ORCID,Sampaio Jorge²¹⁰,Lincopan Nilton¹²^ORCID

Affiliation:

1. Department of Microbiology, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo, Brazil

2. Department of Clinical Analysis, School of Pharmacy, Universidade de São Paulo, São Paulo, Brazil

3. Department of Internal Medicine, School of Veterinary Medicine and Animal Science, Universidade de São Paulo, São Paulo, Brazil

4. School of Veterinary Medicine, Metropolitan University of Santos, Santos, Brazil

5. Laborclin, Pinhais, Brazil

6. Natal Garrison Hospital, Brazilian Army, Natal, Brazil

7. Department of Clinical Analysis, Health Sciences Center, Federal University of Santa Catarina, Florianópolis, Brazil

8. Facultad de Farmacia y Bioquímica, Instituto de Investigaciones en Bacteriologia y Virología Molecular, Universidad de Buenos Aires, Buenos Aires, Argentina

9. Department of Pathology, Clinical and Toxicological Analysis, Health Sciences Center, University Hospital of Londrina, Paraná, Brazil

10. Fleury Medicine and Health, Microbiology Section, São Paulo, Brazil

Abstract

Alerts regarding the emergence and increase of combinations of carbapenemases in Enterobacterales in Latin America and the Caribbean have recently been issued by PAHO and WHO, emphasizing the importance of appropriate microbiological diagnosis and the effective and articulated implementation of infection prevention and control programs. In this study, we evaluated methods based on inhibition of ceftazidime (CAZ), ceftazidime-avibactam (CZA), and aztreonam (ATM) by dipicolinic acid (DPA), EDTA, and avibactam (AVI) inhibitors for the identification of KPC-2- and NDM-1-coexpression in members of the K. pneumoniae complex recovered from human and animal hosts.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Consejo Nacional de Investigaciones Científicas y Técnicas

Agencia Nacional de Investigación y Desarrollo

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01159-22

Reference57 articles.

1. Update on the epidemiology of carbapenemases in Latin America and the Caribbean

2. Carbapenemase-producing Enterobacterales outbreak: Another dark side of COVID-19

3. Pan American Health Organization. 2021. Epidemiological alert: emergence and increase of new combinations of carbapenemases in Enterobacterales in Latin America and the Caribbean 22 October 2021. PAHO/WHO Washington D.C. https://www.paho.org/en/documents/epidemiological-alert-emergence-and-increase-new-combinations-carbapenemases.

4. Comparative Evaluation of Phenotypic Synergy Tests versus RESIST-4 O.K.N.V. and NG Test Carba 5 Lateral Flow Immunoassays for the Detection and Differentiation of Carbapenemases in Enterobacterales and Pseudomonas aeruginosa

5. Coproduction of NDM-1 and KPC-2 in Enterobacter hormaechei from Brazil

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Molecular characterization of carbapenemase-producing Enterobacterales in a tertiary hospital in Lima, Peru;Microbiology Spectrum;2024-01-09

2. Characterisation of a Novel Hybrid IncFIIpHN7A8:IncR:IncN Plasmid Co-Harboring blaNDM-5 and blaKPC-2 from a Clinical ST11 Carbapenem-Resistant Klebsiella pneumoniae Strain;Infection and Drug Resistance;2023-12

3. Emergence of KPC-113 and KPC-114 variants in ceftazidime-avibactam-resistant Klebsiella pneumoniae belonging to high-risk clones ST11 and ST16 in South America;Microbiology Spectrum;2023-10-17

4. Genomic features of an extensively drug-resistant and NDM-1–positive Klebsiella pneumoniae ST340 isolated from river water;Environmental Science and Pollution Research;2023-10-16

5. Klebsiella pneumoniae resistentes a los carbapenémicos en infecciones intrahospitalarias, una revisión en Latinoamérica;Salud, Ciencia y Tecnología;2023-07-24