An Outer Membrane Protein YiaD Contributes to Adaptive Resistance of Meropenem in Acinetobacter baumannii

Author:

Han Lei1ORCID,Gao Yiyuan1,Liu Yuqing1,Yao Siyu1,Zhong Shuyan1,Zhang Sirui1,Wang Jingdan2,Mi Peng13,Wen Yurong45,Ouyang Zhenlin45,Zhang Jing6,Al-Shamiri Mona Mohamed1,Li Pu2,Han Shaoshan7

Affiliation:

1. Department of Microbiology and Immunology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, China

2. School of Public Health, Xi'an Jiaotong University Health Science Center, Xi’an, China

3. Department of Laboratory Medicine, Shaanxi Provincial People’s Hospital, Xi’an, China

4. The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China

5. The Key Laboratory of Environment and Genes Related to Disease of Ministry of Education, Xi'an Jiaotong University Health Science Center, Xi’an, China

6. Department of Laboratory Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

7. Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China

Abstract

Acinetobacter baumannii can develop various resistance mechanisms to carbapenems. However, the factors involved in the evolutionary process that leads from transition to the sensitive to resistant phenotype are not clear.

Funder

National Natural Science Foundation of China

MOE | Fundamental Research Funds for the Central Universities

Innovative Traning Program for College Students

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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