Extent of Oral–Gut Transmission of Bacterial and Fungal Microbiota in Healthy Chinese Adults

Author:

Cheung Man Kit1ORCID,Tong Sylvia L. Y.1,Wong Martin C. S.23,Chan Jason Y. K.4ORCID,Ip Margaret1ORCID,Hui Mamie12ORCID,Lai Christopher K. C.1,Ng Rita W. Y.1,Ho Wendy C. S.1,Yeung Apple C. M.1,Chan Paul K. S.125ORCID,Chen Zigui12ORCID

Affiliation:

1. Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China

2. Centre for Gut Microbiota Research, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China

3. Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China

4. Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China

5. Stanley Ho Centre for Emerging Infectious Diseases, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People’s Republic of China

Abstract

The oral–gut microbiota axis in health is a fundamentally important and clinically relevant topic; however, our current understanding of it remains biased and incomplete. By characterizing the bacterial and fungal microbiomes in paired oral rinse and stool samples from a large cohort of healthy Chinese adults, here we provided new evidence that oral–gut microbiota transmission is limited in non-Western population and across biological domains.

Funder

Research Grants Council, University Grants Committee

Chinese University of Hong Kong

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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