Dissemination of Methicillin-Resistant Staphylococcus aureus Sequence Type 764 Isolates with Mupirocin Resistance in China-Reference-Cited by-同舟云学术

Dissemination of Methicillin-Resistant Staphylococcus aureus Sequence Type 764 Isolates with Mupirocin Resistance in China

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Guo Yinjuan¹,Xu Linling²,Wang Bingjie¹,Rao Lulin³,Xu Yanlei¹,Wang Xinyi¹,Zhao Huilin¹,Yu Jingyi¹,Zhou Ying¹,Yu Fangyou¹^ORCID

Affiliation:

1. Department of Clinical Laboratory, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China

2. Fenyang Affiliated Hospital of Shanxi Medical University, Fenyang, China

3. Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

Abstract

Mupirocin, a topical antibiotic that is commonly used for the nasal decolonization of MRSA and methicillin-sensitive Staphylococcus aureus in hospital settings and nursing homes, was introduced as a highly effective antibiotic against MRSA. Mupirocin acts by competitively binding isoleucyl-tRNA synthetase, thereby disrupting protein synthesis.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03794-22

Reference27 articles.

1. Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research

2. Risk of Methicillin‐ResistantStaphylococcus aureusInfection after Previous Infection or Colonization

3. Mupirocin resistance: clinical implications and potential alternatives for the eradication of MRSA

4. Resistance to and synthesis of the antibiotic mupirocin

5. MupB, a New High-Level Mupirocin Resistance Mechanism in Staphylococcus aureus

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