Effects of Spatial Expression of Activating Transcription Factor 4 on the Pathogenicity of Two Phenotypes of Bovine Viral Diarrhea Virus by Regulating the Endoplasmic Reticulum-Mediated Autophagy Process-Reference-Cited by-同舟云学术

Effects of Spatial Expression of Activating Transcription Factor 4 on the Pathogenicity of Two Phenotypes of Bovine Viral Diarrhea Virus by Regulating the Endoplasmic Reticulum-Mediated Autophagy Process

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Wang Jing¹^ORCID,Chen Ke-Yuan¹,Wang Sheng-Hua²,Liu Yi¹,Zhao Yi-Qing¹,Yang Lan¹,Yang Guang-Hui¹,Wang Xiao-Jia¹,Zhu Yao-Hong¹^ORCID,Yin Jin-hua³,Wang Jiu-Feng¹^ORCID

Affiliation:

1. College of Veterinary Medicine, China Agricultural University, Beijing, China

2. OIE Porcine-Reproductive and Respiratory Syndrome Reference Laboratory, China Animal Disease Control Center, Beijing, China

3. College of Animal Science and Technology, Tarim University, Alar, China

Abstract

The ER-tropic viruses hijack the host cellular ER as the replication platform of the life cycle, which can lead to strong ER stress. The UPR and related transcriptional cascades triggered by ER stress play a crucial role in viral replication and pathogenesis, but little is known about these underlying mechanisms.

Funder

Hainan Province Science and Technology Special Fund

Beijing Dairy Industry Innovation Team

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04225-22

Reference70 articles.