Intracellular Transposition of Mobile Genetic Elements Associated with the Colistin Resistance Gene <i>mcr-1</i>-Reference-Cited by-同舟云学术

Intracellular Transposition of Mobile Genetic Elements Associated with the Colistin Resistance Gene mcr-1

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Goodman Richard N.¹,Tansirichaiya Supathep²^ORCID,Brouwer Michael S. M.³,Roberts Adam P.¹^ORCID

Affiliation:

1. Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

2. Department of Microbiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

3. Wageningen Bioveterinary Research, Lelystad, The Netherlands

Abstract

By analyzing the intracellular transfer of clinically relevant transposons, we can understand the dissemination and evolution of drug resistance conferring mobile genetic elements (MGEs) once a plasmid enters a cell following conjugation. This knowledge will help further our understanding of how these important genes move through bacterial populations. Utilizing the pBACpAK entrapment vector has allowed us to determine the mobility of the novel mcr-1 -containing transposon Tn 7511 .

Funder

UKRI | Medical Research Council

National Institute for Health and Care Research

ZonMw

Ministry of Higher Education, Science, Research and Innovation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03278-22

Reference38 articles.