Single-Cell Transcriptomics To Define Plasmodium falciparum Stage Transition in the Mosquito Midgut

Author:

Mohammed Mubasher1,Dziedziech Alexis1,Sekar Vaishnovi2,Ernest Medard3,Alves E Silva Thiago Luiz3,Balan Balu45,Emami S. Noushin1,Biryukova Inna2,Friedländer Marc R.2,Jex Aaron45ORCID,Jacobs-Lorena Marcelo6,Henriksson Johan7,Vega-Rodriguez Joel3,Ankarklev Johan18ORCID

Affiliation:

1. Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden

2. Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden

3. Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA

4. Population Health and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia

5. Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia

6. Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA

7. Laboratory for Molecular Infection Medicine Sweden (MIMS), Department of Molecular Biology, Umeå University, Umeå, Sweden

8. Microbial Single Cell Genomics, Department of Cell and Molecular Biology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

Abstract

The malaria parasite Plasmodium falciparum causes more than half a million deaths per year. The current treatment regimen targets the symptom-causing blood stage inside the human host.

Funder

The Swedish Society for Medical Research

The Jeansson Foundation

NIH Distinguished Scholars Program

HHS | National Institutes of Health

Science for Life Laboratory

Vetenskapsrådet

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference70 articles.

1. World Health Organization. 2021. World malaria report 2021. World Health Organization Geneva Switzerland. https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2021. Retrieved 3 March 2022.

2. The roles of temperature, pH and mosquito factors as triggers of male and female gametogenesis of Plasmodium berghei in vitro

3. The Plasmodium bottleneck: malaria parasite losses in the mosquito vector

4. When Is a Plasmodium-Infected Mosquito an Infectious Mosquito?

5. Plasmodium falciparum genetic crosses in a humanized mouse model

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