Deep Sequencing of HPV16 E6 Region Reveals Unique Mutation Pattern of HPV16 and Predicts Cervical Cancer-Reference-Cited by-同舟云学术

Deep Sequencing of HPV16 E6 Region Reveals Unique Mutation Pattern of HPV16 and Predicts Cervical Cancer

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ai Wenchao¹^ORCID,Wu Chuanyong²,Jia Liqing³,Xiao Xiao²,Xu Xuewen²,Ren Min³,Xue Tian³,Zhou Xiaoyan³,Wang Ying¹,Gao Chunfang¹²^ORCID

Affiliation:

1. Department of Laboratory Medicine, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China

2. Clinical Laboratory Medicine Center, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China

3. Department of Pathology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China

Abstract

The study provides evidence for the first time that HPV16 E6 sequences contain vital mutation features in predicting the high‐grade squamous intraepithelial lesion and can reduce even more unneeded colposcopies without a loss of sensitivity to detect cervical cancer. Moreover, the D32E and H85Y variants of E6 exhibited a significantly higher ability to degrade p53, which may play a vital role in the development of cervical cancer.

Funder

Innovation Group Project of Shanghai Municipal Health Commission

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01401-22

Reference41 articles.

1. The HPV E6/E7 Oncogenes: Key Factors for Viral Carcinogenesis and Therapeutic Targets

2. Em FJ, Lam F, Colombet M, Mery L, Piñeros M, Znaor A, Soerjomataram I, Bray F. 2020. Global Cancer Observatory: cancer today. International Agency for Research on Cancer, Lyon, France.

3. Mechanisms of Human Papillomavirus-Induced Oncogenesis

4. Human papillomavirus types in 115,789 HPV-positive women: A meta-analysis from cervical infection to cancer

5. EUROGIN 2011 roadmap on prevention and treatment of HPV-related disease

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. HPV-16 E6 mutation and viral integration related host DNA methylation implicate the development and progression of cervical cancer;Infectious Diseases;2024-08-18

2. Amino Acid Substitution Patterns in the E6 and E7 Proteins of HPV Type 16: Phylogeography and Evolution;Molecular Biology;2024-08

3. HPV16 Phylogenetic Variants in Anogenital and Head and Neck Cancers: State of the Art and Perspectives;Viruses;2024-06-03

4. Phylogenetic analysis and antigenic epitope prediction for E6 and E7 of Alpha-papillomavirus 9 in Taizhou, China;BMC Genomics;2024-05-22

5. Lightweight Low-Rank Adaptation Vision Transformer Framework for Cervical Cancer Detection and Cervix Type Classification;Bioengineering;2024-05-08