Penicillin-Binding Protein Occupancy Dataset for 18 β-Lactams and 4 β-Lactamase Inhibitors in Neisseria gonorrhoeae-Reference-Cited by-同舟云学术

Penicillin-Binding Protein Occupancy Dataset for 18 β-Lactams and 4 β-Lactamase Inhibitors in Neisseria gonorrhoeae

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

López-Argüello Silvia¹,Montaner Maria¹,Mármol-Salvador Amanda¹,Velázquez-Escudero Ana²³,Docobo-Pérez Fernando²³⁴^ORCID,Oliver Antonio¹⁴^ORCID,Moya Bartolome¹⁴^ORCID

Affiliation:

1. Servicio de Microbiología and Unidad de Investigación, Hospital Universitario Son Espases, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain

2. Departamento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Seville, Spain

3. Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, Seville, Spain

4. Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Madrid, Spain

Abstract

The manuscript represents the first N. gonorrhoeae PBP-binding data set for 22 chemically different drugs in two type strains with different genetic background. We have identified three clusters of drugs according to their PBP binding IC 50 s and highlighted the binding differences across the two strains studied.

Funder

Govern de les Illes Balears

MEC | Instituto de Salud Carlos III

MEC | Agencia Estatal de Investigación

HHS | NIH | National Institute of Allergy and Infectious Diseases

EC | European Regional Development Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00692-23

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