Rapid On-Site Detection of Extensively Drug-Resistant Genes in <i>Enterobacteriaceae</i> via Enhanced Recombinase Polymerase Amplification and Lateral Flow Biosensor-Reference-Cited by-同舟云学术

Rapid On-Site Detection of Extensively Drug-Resistant Genes in Enterobacteriaceae via Enhanced Recombinase Polymerase Amplification and Lateral Flow Biosensor

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Tao Jin¹,Liu Dejun¹,Xiong Jincheng¹,Dou Leina¹,Zhai Weishuai¹^ORCID,Zhang Rong²^ORCID,Wang Yang¹^ORCID,Shen Jianzhong¹^ORCID,Wen Kai¹

Affiliation:

1. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of China

2. Clinical Microbiology Laboratory, 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China

Abstract

Carbapenem, colistin, and tigecycline are considered the last resorts for treating severe bacterial infections caused by extensively drug-resistant (XDR) pathogens. A major threat to public health is the emergence and prevalence of transferable XDR genes in Enterobacteriaceae , such as bla NDM and bla KPC for carbapenem resistance, mcr-1 for colistin resistance, and tet (X4) and tet (X6) for tigecycline resistance.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03344-22

Reference34 articles.

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3. Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans

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5. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

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