Molecular Basis of the Toxigenic Vibrio cholerae O1 Serotype Switch from Ogawa to Inaba in Haiti-Reference-Cited by-同舟云学术

Molecular Basis of the Toxigenic Vibrio cholerae O1 Serotype Switch from Ogawa to Inaba in Haiti

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Paisie Taylor K.¹²,Cash Melanie N.¹²,Tagliamonte Massimiliano S.¹²^ORCID,Ali Afsar²³,Morris J. Glenn²⁴^ORCID,Salemi Marco¹²^ORCID,Mavian Carla¹²^ORCID

Affiliation:

1. Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA

2. Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA

3. Department of Environmental and Global Health, College of Public Health and Health Profession, University of Florida, Gainesville, Florida, USA

4. Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA

Abstract

Our phylodynamic analysis demonstrated that Vibrio cholerae Inaba strains in Haiti evolved directly from Ogawa strains. Our results support the hypothesis that after an initial Ogawa-dominated epidemic wave, V. cholerae Inaba was able to become the dominant strain thanks to a selective advantage driven by ongoing diversifying selection, independently from the mutational pattern in the wbeT gene.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03624-22

Reference28 articles.

1. Mutations in therfbTGene Are Responsible for the Ogawa to Inaba Serotype Conversion inVibrio choleraeO1

2. Serotype conversion in Vibrio cholerae O1.

3. Major Shift of Toxigenic V. cholerae O1 from Ogawa to Inaba Serotype Isolated from Clinical and Environmental Samples in Haiti