Mycobacterium tuberculosis Rv1324 Protein Contributes to Mycobacterial Persistence and Causes Pathological Lung Injury in Mice by Inducing Ferroptosis-Reference-Cited by-同舟云学术

Mycobacterium tuberculosis Rv1324 Protein Contributes to Mycobacterial Persistence and Causes Pathological Lung Injury in Mice by Inducing Ferroptosis

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Shi Xiaoxia¹²,Li Chunyu¹,Cheng Lin¹,Ullah Hayan¹,Sha Shanshan¹,Kang Jian¹,Ma Xiaochi³⁴,Ma Yufang¹⁵^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, China

2. Department of Experimental Teaching Center of Public Health, Dalian Medical University, Dalian, China

3. College of Integrative Medicine, Dalian Medical University, Dalian, China

4. Pharmaceutical Research Center, The Second Affiliated Hospital, Dalian Medical University, Dalian, China

5. Department of Microbiology, Dalian Medical University, Dalian, China

Abstract

The intracellular survival of M. tuberculosis (Mtb) plays a crucial role in its pathogenesis, which depends on various Mtb oxidoreductases that are resistant to reactive oxygen and nitrogen species (ROS and RNS) that are generated by the host during Mtb infection. Secretory protein Rv1324 is a potential virulence factor of Mtb and is a possible thioredoxin that has oxidoreductase activity against ROS and RNS during Mtb infection.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02526-22

Reference54 articles.

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