A Resistance Mechanism in Non- mcr Colistin-Resistant Escherichia coli in Taiwan: R81H Substitution in PmrA Is an Independent Factor Contributing to Colistin Resistance-Reference-Cited by-同舟云学术

A Resistance Mechanism in Non- mcr Colistin-Resistant Escherichia coli in Taiwan: R81H Substitution in PmrA Is an Independent Factor Contributing to Colistin Resistance

Published:2021-09-03 Issue:1 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Wang Ching-Hsun¹,Siu L. Kristopher²,Chang Feng-Yee³,Chiu Sheng-Kang³,Lin Jung-Chung³

Affiliation:

1. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan

2. Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Miaoli, Taiwan

3. Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

Abstract

The molecular epidemiology and resistance mechanisms of mcr -negative colistin-resistant E. coli are not well described. In this study, a total of 11 mcr -negative colistin-resistant E. coli isolates were selected from a nationwide antimicrobial resistance surveillance program in Taiwan for further investigation.

Funder

Tri-Service General Hospital

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00022-21

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Molecular mechanisms related to colistin resistance in Enterobacteriaceae