A Candidate Gene Cluster for the Bioactive Natural Product Gyrophoric Acid in Lichen-Forming Fungi-Reference-Cited by-同舟云学术

A Candidate Gene Cluster for the Bioactive Natural Product Gyrophoric Acid in Lichen-Forming Fungi

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Singh Garima¹²³^ORCID,Calchera Anjuli¹,Merges Dominik¹,Valim Henrique¹,Otte Jürgen¹,Schmitt Imke¹²⁴,Dal Grande Francesco¹²³

Affiliation:

1. Senckenberg Biodiversity and Climate Research Centre (SBiK-F), Frankfurt, Germany

2. LOEWE Center for Translational Biodiversity Genomics (TBG), Frankfurt, Germany

3. Department of Biology, University of Padova, Padua, Italy

4. Institute of Ecology, Diversity and Evolution, Goethe University, Frankfurt, Germany

Abstract

The implementation of natural products in the pharmaceutical industry relies on the possibility of modifying the natural product (NP) pathway to optimize yields and pharmacological effects. Characterization of genes and pathways underlying natural product biosynthesis is a major bottleneck for exploiting the medicinal properties of the natural products.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00109-22

Reference64 articles.

1. Natural Products as Sources of New Drugs from 1981 to 2014

2. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

3. Natural Products as Sources of New Drugs over the Last 25 Years

4. Emerging molecular biology tools and strategies for engineering natural product biosynthesis

5. Synthetic biology and metabolic engineering of actinomycetes for natural product discovery

Cited by 16 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Geministatins: new depside antibiotics from the fungus Austroacremonium gemini;The Journal of Antibiotics;2024-06-26

2. Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A;Angewandte Chemie International Edition;2024-03-27

3. Are there conserved biosynthetic genes in lichens? Genome-wide assessment of terpene biosynthetic genes suggests conserved evolution of the squalene synthase cluster;2024-01-25

4. Lichens;The Mycota;2024

5. Circadian clock‐ and temperature‐associated genes contribute to overall genomic differentiation along elevation in lichenized fungi;Molecular Ecology;2023-12-26