<i>In Vitro</i> Activity of Two Cefepime-Based Novel Combinations, Cefepime/Taniborbactam and Cefepime/Zidebactam, against Carbapenemase-Expressing <i>Enterobacterales</i> Collected in India-Reference-Cited by-同舟云学术

In Vitro Activity of Two Cefepime-Based Novel Combinations, Cefepime/Taniborbactam and Cefepime/Zidebactam, against Carbapenemase-Expressing Enterobacterales Collected in India

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Bakthavatchalam Yamuna Devi¹,Elangovan Divyaa²,Jaganathan Subha Vajjiravelu³,Subburaju Nivedhana⁴,Shankar Abirami¹,Manokaran Yuvasri¹,J. Sudarsana⁵,Devi Rema⁶,Baveja Sujata⁷,Devi Sheela⁸,S. Jayakumar⁹,Bhattacharya Sanjay¹⁰,S. M. Rudresh¹¹,Yesudhason Bineshlal¹,Shetty Vignesh¹²,Mutreja Ankur¹²,Manesh Abi¹³^ORCID,Varghese George M.¹³,Marwick Charis A.¹⁴,Parcell Benjamin J.¹⁵,Gilbert Ian H.¹⁶^ORCID,Veeraraghavan Balaji¹^ORCID

Affiliation:

1. Department of Clinical Microbiology, Christian Medical College and Hospital, Vellore, India

2. Department of Microbiology, Panimalar Medical College Hospital and Research Institute, Chennai, India

3. Department of Microbiology, Meenakshi Medical College and Research Institute, Kanchipuram, India

4. Department of Microbiology, Rainbow Children’s Hospital and Perinatal Care, Hyderabad, India

5. Department of Microbiology, Baby Memorial Hospital, Kozhikode, India

6. Department of Microbiology, Dr. Somervell Memorial CSI Medical College and Hospital, Thiruvananthapuram, India

7. Department of Microbiology, Lokmanya Tilak Municipal General Hospital and Medical College (Sion Hospital), Mumbai, India

8. Department of Microbiology, Pondicherry Institute of Medical Sciences, Kalapet, India

9. Department of Microbiology, Saveetha Medical College and Hospital, Chennai, India

10. Department of Microbiology, Tata Medical Center, Kolkata, India

11. Department of Microbiology, ESI Post Graduate Institute of Medical Science and Research, Bengaluru, India

12. Department of Medicine, Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), University of Cambridge, Cambridge, United Kingdom

13. Department of Infectious Disease, Christian Medical College and Hospital, Vellore, India

14. Population Health and Genomics, University of Dundee, Dundee, United Kingdom

15. Ninewells Hospital and Medical School, Dundee, United Kingdom

16. Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom

Abstract

The study revealed the differential ability of cefepime/taniborbactam and cefepime/zidebactam in tackling carbapenemase-producing Indian clinical isolates that also harbored additional mechanisms of resistance. NDM-expressing E. coli with 4-amino-acid insert in PBP3 are predominately resistant to cefepime/taniborbactam, while the β-lactam enhancer mechanism-based cefepime/zidebactam showed consistent activity against single- or dual-carbapenemase-producing isolates including E. coli with PBP3 inserts.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04925-22

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