High-Throughput Profiling of Candida auris Isolates Reveals Clade-Specific Metabolic Differences

Author:

Brandt Philipp1,Mirhakkak Mohammad H.2,Wagner Lysett1,Driesch Dominik3,Möslinger Anna14,Fänder Pauline1,Schäuble Sascha2,Panagiotou Gianni2,Vylkova Slavena1ORCID

Affiliation:

1. Septomics Research Center, Friedrich Schiller University, and Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany

2. Systems Biology and Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany

3. BioControl Jena, Jena, Germany

4. Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany

Abstract

Four main clades of the emerging, multidrug-resistant human pathogen Candida auris have been identified, and they differ in their susceptibilities to antifungals and disinfectants. Moreover, clade- and strain-specific metabolic differences have been identified, but a comprehensive overview of nutritional characteristics and resistance to various stressors is missing.

Funder

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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