Lipid and Nucleocapsid N-Protein Accumulation in COVID-19 Patient Lung and Infected Cells-Reference-Cited by-同舟云学术

Lipid and Nucleocapsid N-Protein Accumulation in COVID-19 Patient Lung and Infected Cells

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Grootemaat Anita E.¹,van der Niet Sanne¹,Scholl Edwin R.¹,Roos Eva²,Schurink Bernadette²,Bugiani Marianna²,Miller Sara E.³,Larsen Per¹²,Pankras Jeannette¹²,Reits Eric A.¹,van der Wel Nicole N.¹^ORCID

Affiliation:

1. Electron Microscopy Centre Amsterdam, Medical Biology, Amsterdam University Medical Centre (UMC), Amsterdam, the Netherlands

2. Department of Pathology, Amsterdam University Medical Centers (UMC), VU University Amsterdam, Amsterdam, the Netherlands

3. Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA

Abstract

Visualization of the subcellular localization of SARS-CoV-2 proteins in lung patient material of COVID-19 patients is important for the understanding of this new virus. We detected viral proteins in the context of the ultrastructure of infected cells and tissues and discovered that some viral proteins accumulate in novel, lipid-filled compartments.

Funder

Amsterdam UMC Corona research fund

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01271-21

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