Mechanisms of Qingyi Decoction in Severe Acute Pancreatitis-Associated Acute Lung Injury via Gut Microbiota: Targeting the Short-Chain Fatty Acids-Mediated AMPK/NF-κB/NLRP3 Pathway-Reference-Cited by-同舟云学术

Mechanisms of Qingyi Decoction in Severe Acute Pancreatitis-Associated Acute Lung Injury via Gut Microbiota: Targeting the Short-Chain Fatty Acids-Mediated AMPK/NF-κB/NLRP3 Pathway

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Wang Zhengjian¹²³,Liu Jin¹²³,Li Fan¹²³,Ma Shurong¹³,Zhao Liang¹²,Ge Peng¹²³,Wen Haiyun¹²³,Zhang Yibo¹²³,Liu Xiaojun²³⁴,Luo Yalan¹²³,Yao Jiaqi²³⁴,Zhang Guixin¹²³,Chen Hailong¹³^ORCID

Affiliation:

1. Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China

2. Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, People’s Republic of China

3. Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China

4. Department of Anesthesiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China

Abstract

Gut microbiota affects the severity of SAP-ALI and intestinal barrier function. During SAP, a significant increase in the relative abundance of gut pathogens ( Escherichia , Enterococcus , Enterobacter , Peptostreptococcus , Helicobacter ) was observed.

Funder

MOST | National Key Research and Development Program of China

MOST | National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03664-22

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