IL-6 Prevents Lung Macrophage Death and Lung Inflammation Injury by Inhibiting GSDME- and GSDMD-Mediated Pyroptosis during Pneumococcal Pneumosepsis-Reference-Cited by-同舟云学术

IL-6 Prevents Lung Macrophage Death and Lung Inflammation Injury by Inhibiting GSDME- and GSDMD-Mediated Pyroptosis during Pneumococcal Pneumosepsis

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Gou Xuemei¹²^ORCID,Xu Wenchun¹,Liu Yusi³,Peng Yang¹,Xu Wenlong¹,Yin Yibing¹,Zhang Xuemei¹^ORCID

Affiliation:

1. Key Laboratory of Diagnostic Medicine Designated by the Ministry of Education, Chongqing Medical University, Chongqing, China

2. Department of Laboratory Medicine, Yongchuan Hospital of Chongqing Medical University, Chongqing, China

3. Department of Laboratory Medicine, First Hospital of China Medical University, Shenyang, China

Abstract

Pneumococcal pneumonia has been a significant cause of morbidity and mortality throughout human history. Failing to control pneumococcal pneumonia and resolve ongoing inflammation in a host can cause sepsis, namely pneumococcal pneumosepsis, and death ensues. Few theories have suggested an optimally therapeutic option for this infectious disease.

Funder

General Project of the National Natural Science Foundation of China

Youth Project of the National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02049-21

Reference35 articles.

1. Pneumococcal Colonization and Virulence Factors Identified Via Experimental Evolution in Infection Models

2. The co-pathogenesis of influenza viruses with bacteria in the lung