Spike Protein Cleavage-Activation in the Context of the SARS-CoV-2 P681R Mutation: an Analysis from Its First Appearance in Lineage A.23.1 Identified in Uganda-Reference-Cited by-同舟云学术

Spike Protein Cleavage-Activation in the Context of the SARS-CoV-2 P681R Mutation: an Analysis from Its First Appearance in Lineage A.23.1 Identified in Uganda

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Lubinski Bailey¹²,Frazier Laura E.¹,Phan My V. T.³,Bugembe Daniel L.³,Cunningham Jessie L.¹,Tang Tiffany⁴,Daniel Susan⁴,Cotten Matthew³⁵,Jaimes Javier A.²^ORCID,Whittaker Gary R.²⁶^ORCID

Affiliation:

1. Graduate Program in Biological & Biomedical Sciences, Cornell University, Ithaca, New York, USA

2. Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA

3. MRC/UVRI and London School of Hygiene and Tropical Medicine – Uganda Research Unit, Entebbe, Uganda

4. Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, USA

5. MRC Centre of Virus Research, University of Glasgow, Glasgow, United Kingdom

6. Department of Public and Ecosystem Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA

Abstract

During the course of the SARS-CoV-2 pandemic, viral variants have emerged that often contain notable mutations in the spike gene. Mutations that encode changes in the spike S1/S2 (furin) activation site have been considered especially impactful.

Funder

HHS | National Institutes of Health

National Science Foundation

UKRI | Medical Research Council

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01514-22

Reference37 articles.