The <i> vanR <sub>Cd</sub> </i> Mutation 343A>G, Resulting in a Thr115Ala Substitution, Is Associated with an Elevated Minimum Inhibitory Concentration (MIC) of Vancomycin in Clostridioides difficile Clinical Isolates from Florida-Reference-Cited by-同舟云学术

The vanR _Cd Mutation 343A>G, Resulting in a Thr115Ala Substitution, Is Associated with an Elevated Minimum Inhibitory Concentration (MIC) of Vancomycin in Clostridioides difficile Clinical Isolates from Florida

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Wickramage Ishani¹^ORCID,Peng Zhong¹,Chakraborty Soumyadeep¹,Harmanus Céline²,Kuijper Ed J.²³^ORCID,Alrabaa Sally⁴,Smits Wiep Klaas²^ORCID,Sun Xingmin¹^ORCID

Affiliation:

1. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA

2. Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

3. National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

4. Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA

Abstract

The perpetually evolving antimicrobial resistance (AMR) of C. difficile is an important contributor to its epidemiology and is a grave concern to global public health. This exacerbates the challenge of treating the infections caused by this multidrug-resistant causative organism of potentially life-threatening diarrhea.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03777-22

Reference25 articles.

1. Genetic Mechanisms of Vancomycin Resistance in Clostridioides difficile: A Systematic Review

2. Emergence and global spread of epidemic healthcare-associated Clostridium difficile

3. Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)

4. Vancomycin Resistance in Gram-Positive Cocci

5. The functionalvanGCdcluster ofClostridium difficiledoes not confer vancomycin resistance

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