Enhanced Rishirilide Biosynthesis by a Rare In-Cluster Phosphopantetheinyl Transferase in Streptomyces xanthophaeus-Reference-Cited by-同舟云学术

Enhanced Rishirilide Biosynthesis by a Rare In-Cluster Phosphopantetheinyl Transferase in Streptomyces xanthophaeus

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Zhang Songya¹,Fan Shuai²,Zhu Jing¹,Zhou Liying³,Yan Xiaohui⁴,Yang Zhaoyong²,Si Tong¹,Liu Tao³^ORCID

Affiliation:

1. CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

2. The Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

3. Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang, China

4. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China

Abstract

Genome mining has been a vital means for natural product drug discovery in the postgenomic era. The rishirilide-type polyketides have attracted attention due to their potent bioactivity, but the poor robustness of production hosts has limited further research and development.

Funder

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Natural Science Foundation of Liaoning Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03247-22

Reference48 articles.

1. The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life