Performance of Hepatitis C Virus (HCV) Core Antigen Assay in the Diagnosis of Recently Acquired HCV Infection among High-Risk Populations-Reference-Cited by-同舟云学术

Performance of Hepatitis C Virus (HCV) Core Antigen Assay in the Diagnosis of Recently Acquired HCV Infection among High-Risk Populations

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Sun Hsin-Yun¹,Liu Wang-Da¹²,Wang Chih-Wen³,Wei Yu-Ju⁴,Lin Kuan-Yin¹,Huang Yu-Shan¹,Su Li-Hsin¹,Chen Yi-Ting¹,Liu Wen-Chun¹,Su Yi-Chin¹,Chen Yea-Wen¹,Chuang Yu-Chung¹,Lu Po-Liang⁴,Hung Chien-Ching¹⁵⁶⁷,Yu Ming-Lung³⁸⁹^ORCID

Affiliation:

1. Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

2. Department of Medicine, National Taiwan University Cancer Center, Taipei, Taiwan

3. Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

4. Department of Internal Medicine, Kaohsiung Medical University Hospital and College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

5. Department of Tropical Medicine and Parasitology, National Taiwan University College of Medicine, Taipei, Taiwan

6. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

7. China Medical University, Taichung, Taiwan

8. School of Medicine and Hepatitis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

9. Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan

Abstract

The HCV core antigen assay has a high specificity of 99.4% and negative predictive value of 99.5% but a lower sensitivity of 87.1% and positive predictive value of 85.7% in the diagnosis of recently acquired HCV infection in high-risk populations. Our findings are informative for many countries confronted with limited resources to timely identify acute HCV infections and provide effective direct-acting antivirals to halt onward transmission.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00345-22

Reference34 articles.

1. A Focused Review on Recent Advances in the Diagnosis and Treatment of Viral Hepatitis

2. Management and Treatment of Hepatitis C: Are There Still Unsolved Problems and Unique Populations?

3. Incidence of HCV Reinfection Among HIV-Positive MSM and Its Association With Sexual Risk Behavior: A Longitudinal Analysis

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