Trivalent NDV-HXP-S Vaccine Protects against Phylogenetically Distant SARS-CoV-2 Variants of Concern in Mice-Reference-Cited by-同舟云学术

Trivalent NDV-HXP-S Vaccine Protects against Phylogenetically Distant SARS-CoV-2 Variants of Concern in Mice

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

González-Domínguez Irene¹^ORCID,Martínez Jose Luis¹,Slamanig Stefan¹^ORCID,Lemus Nicholas¹,Liu Yonghong¹,Lai Tsoi Ying¹,Carreño Juan Manuel¹,Singh Gagandeep¹^ORCID,Singh Gagandeep¹²^ORCID,Schotsaert Michael¹²,Mena Ignacio¹²,McCroskery Stephen¹,Coughlan Lynda³⁴^ORCID,Krammer Florian¹⁵^ORCID,García-Sastre Adolfo¹²⁵⁶⁷^ORCID,Palese Peter¹⁶,Sun Weina¹^ORCID

Affiliation:

1. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

2. Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

3. Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA

4. Center for Vaccine Development and Global Health (CVD), University of Maryland School of Medicine, Baltimore, Maryland, USA

5. Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

6. Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

7. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

Abstract

This manuscript describes an extended work on the Newcastle disease virus (NDV)-based vaccine focusing on multivalent formulations of NDV vectors expressing different prefusion-stabilized versions of the spike proteins of different SARS-CoV-2 variants of concern (VOC). We demonstrate here that this low-cost NDV platform can be easily adapted to construct vaccines against SARS-CoV-2 variants.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | National Institutes of Health

Anonymous philanthropist to Mount Sinai

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01538-22

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