Genomic and Functional Characterization of Longitudinal Pseudomonas aeruginosa Isolates from Young Patients with Cystic Fibrosis-Reference-Cited by-同舟云学术

Genomic and Functional Characterization of Longitudinal Pseudomonas aeruginosa Isolates from Young Patients with Cystic Fibrosis

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Chandler Courtney E.¹^ORCID,Hofstaedter Casey E.¹²^ORCID,Hazen Tracy H.³⁴,Rasko David A.¹³⁴⁵^ORCID,Ernst Robert K.¹⁵^ORCID

Affiliation:

1. Department of Microbial Pathogenesis, University of Maryland—Baltimore, Baltimore, Maryland, USA

2. Medical Scientist Training Program, University of Maryland School of Medicine, Baltimore, Maryland, USA

3. Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA

4. Department of Microbiology and Immunology, University of Maryland—Baltimore, Baltimore, Maryland, USA

5. Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, Maryland, USA

Abstract

Chronic lung infection with Pseudomonas aeruginosa is of major concern for patients with cystic fibrosis (CF). During infection, P. aeruginosa undergoes genomic and functional adaptation to the hyperinflammatory CF airway, resulting in worsening lung function and pulmonary decline.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Cystic Fibrosis Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01556-23

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