Whole-Genome Shotgun Metagenomic Sequencing Reveals Distinct Gut Microbiome Signatures of Obese Cats

Author:

Ma Xiaolei12,Brinker Emily1,Graff Emily C.13,Cao Wenqi1,Gross Amanda L.3,Johnson Aime K.4,Zhang Chao5,Martin Douglas R.36,Wang Xu1378ORCID

Affiliation:

1. Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA

2. School of Life Sciences and Technology, Tongji University, Shanghai, China

3. Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA

4. Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA

5. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Institute of Precision Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China

6. Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA

7. Center for Advanced Science, Innovation and Commerce, Alabama Agricultural Experiment Station, Auburn, Alabama, USA

8. HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA

Abstract

Obesity affects around 45% of domestic cats, and licensed drugs for treating feline obesity are lacking. Physical exercise and calorie restrictions are commonly used for weight loss but with limited efficacy.

Funder

U.S. Department of Agriculture

National Science Foundation

Alabama EPSCoR

Auburn University

AU | College of Veterinary Medicine, Auburn University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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