Species-Wide Phylogenomics of the Staphylococcus aureus <i>Agr</i> Operon Revealed Convergent Evolution of Frameshift Mutations-Reference-Cited by-同舟云学术

Species-Wide Phylogenomics of the Staphylococcus aureus Agr Operon Revealed Convergent Evolution of Frameshift Mutations

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Raghuram Vishnu¹^ORCID,Alexander Ashley M.²^ORCID,Loo Hui Qi³^ORCID,Petit Robert A.⁴^ORCID,Goldberg Joanna B.⁵^ORCID,Read Timothy D.⁴^ORCID

Affiliation:

1. Microbiology and Molecular Genetics Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, Georgia, USA

2. Population Biology, Ecology, and Evolution Program, Graduate Division of Biological and Biomedical Sciences, Laney Graduate School, Emory University, Atlanta, Georgia, USA

3. Department of Biology, Emory University, Atlanta, Georgia, USA

4. Division of Infectious Diseases, Department of Medicine, Emory University, Atlanta, Georgia, USA

5. Division of Pulmonary, Allergy and Immunology, Cystic Fibrosis, and Sleep, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA

Abstract

Staphylococcus aureus is a globally pervasive pathogen that produces a plethora of toxic molecules that can harm host immune cells. Production of these toxins is mainly controlled by an active agr quorum-sensing system, which senses and responds to bacterial cell density.

Funder

Cystic Fibrosis Foundation

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01334-21

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