Genomic and Chemical Decryption of the Bacteroidetes Phylum for Its Potential to Biosynthesize Natural Products

Author:

Brinkmann Stephan1ORCID,Kurz Michael2,Patras Maria A.1,Hartwig Christoph1,Marner Michael1ORCID,Leis Benedikt1,Billion André1,Kleiner Yolanda1,Bauer Armin2,Toti Luigi2,Pöverlein Christoph2,Hammann Peter E.3,Vilcinskas Andreas14ORCID,Glaeser Jens13,Spohn Marius1,Schäberle Till F.14ORCID

Affiliation:

1. Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch for Bioresources, Giessen, Germany

2. Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany

3. Evotec International GmbH, Göttingen, Germany

4. Institute for Insect Biotechnology, Justus-Liebig-University Giessen, Giessen, Germany

Abstract

The development of pipelines for anti-infectives to be applied in plant, animal, and human health management are dried up. However, the resistance development against compounds in use calls for new lead structures.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference117 articles.

1. Bacterial phylogeny structures soil resistomes across habitats

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4. The Scourge of Antibiotic Resistance: The Important Role of the Environment

5. UN Interagency Coordination Group (IACG) on Antimicrobial Resistance. 2019. No time to wait: Securing the future from drug-resistant infections. https://www.who.int/antimicrobial-resistance/interagency-coordination-group/final-report/en/. Accessed June 4 2020.

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