Caspofungin Cerebral Penetration and Therapeutic Efficacy in Experimental Cerebral Aspergillosis-Reference-Cited by-同舟云学术

Caspofungin Cerebral Penetration and Therapeutic Efficacy in Experimental Cerebral Aspergillosis

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ullmann Irina¹²,Aregger Andrea¹³,Leib Stephen L.¹^ORCID,Zimmerli Stefan¹⁴^ORCID

Affiliation:

1. Institute for Infectious Diseases, University of Bern, Bern, Switzerland

2. Clinic of General Internal and Emergency Medicine, Citizens Hospital Solothurn, Solothurn, Switzerland

3. Center for Intensive Care Medicine, Lucerne Cantonal Hospital, Lucerne, Switzerland

4. Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland

Abstract

Treatment options for cerebral aspergillosis, an often-lethal disease, are limited. The echinocandins (caspofungin is one of them) are not recommended treatment because their brain tissue penetration is often considered insufficient.

Funder

Merck & Co. | Merck Sharp and Dohme

Gilead Sciences

Pfizer

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02753-21

Reference35 articles.

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4. Localization of Aspergillosis to the Central Nervous System Among Patients with Acute Leukemia: Report of 14 Cases

5. Efficacy of Amphotericin B or Itraconazole in a Murine Model of Central Nervous System Aspergillus Infection

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