Metatranscriptome Reveals Specific Immune and Microbial Signatures of Respiratory Syncytial Virus Infection in Children

Author:

Feng Qianyu12,Feng Ziheng12,Yang Bin3,Han Shuaibing12,Wen Shunhang4,Lu Gen5,Jin Rong5,Xu Baoping6,Zhang Hailin4,Xu Lili12ORCID,Xie Zhengde12ORCID

Affiliation:

1. Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, National Key Discipline of Pediatrics (Capital Medical University), Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China

2. Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, China

3. Vision Medicals Center for Infectious Diseases, Guangzhou, Guangdong, China

4. Department of Children’s Respiration disease, the Second Affiliated Hospital & Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China

5. Guiyang Women and Children Healthcare Hospital, Guiyang, Guizhou, China

6. Department of Respiratory Diseases I, Beijing Children’s Hospital, Capital Medical University, National Clinical Research Center for Respiratory Diseases, National Center for Children’s Health, Beijing, China

Abstract

In the present study, we demonstrated the comparative results of host responses to infection between RSV and other three common respiratory viruses for children. The comparative transcriptomics study of respiratory samples sheds light on the significant roles that ciliary organization and assembly, extracellular matrix changes, and microbial interactions play in the pathogenesis of RSV infection.

Funder

National Natural Science Foundation of China

CAMS Innovation Fund for Medical Sciences

Natural Science Foundation of Beijing Municipality

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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