Genetic Evidence in Favor of a Polyketide Origin of Acremeremophilanes, the Fungal “Sesquiterpene” Metabolites

Abstract

The article contradicts the established fact that acremeremophilane metabolites produced by fungi are sesquiterpenes; instead, our findings suggest that at least some of these well-studied metabolites are of polyketide origin. Acremeremophilane metabolites are of medicinal significance, and the present findings have implications for the metabolic engineering of these metabolites and also their overproduction in microbial cell factories.