Braun Lipoprotein Protects against Escherichia coli-Induced Inflammatory Responses and Lethality in Mice-Reference-Cited by-同舟云学术

Braun Lipoprotein Protects against Escherichia coli-Induced Inflammatory Responses and Lethality in Mice

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Shen Yuan¹²³,Gong Zhiguo¹²,Zhang Shuangyi¹²,Cao Jinshan¹²,Mao Wei¹²,Fu Yunhe⁴,Su Niri⁴,Ding Yulin²,Zhao Jiamin¹²,Gu Baichen¹²,Feng Shuang⁵²,Liu Bo¹²^ORCID

Affiliation:

1. Laboratory of Veterinary Clinical Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China

2. Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, Inner Mongolia Agricultural University, Hohhot, China

3. School of Public Health, Inner Mongolia Medical University, Hohhot, China

4. Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, China

5. Laboratory of Veterinary Public Health, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China

Abstract

In this study, we investigated the roles of bacterial outer membrane component BLP in regulating inflammatory responses and lethality in mice that were induced by a ubiquitous and serious pathogen, Escherichia coli . BLP could alleviate the mortality of mice and organ damage, as well as decrease proinflammatory cytokines and chemokine production and enhance anti-inflammatory cytokine production in mouse serum and organs.

Funder

Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region

National Natural Science Foundation of China

Natural Science Foundation of Inner Mongolia

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03541-22

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