Anidulafungin Treatment Blocks the Sexual Cycle of Pneumocystis murina and Prevents Growth and Survival without Rescue by an Alternative Mode of Replication-Reference-Cited by-同舟云学术

Anidulafungin Treatment Blocks the Sexual Cycle of Pneumocystis murina and Prevents Growth and Survival without Rescue by an Alternative Mode of Replication

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Cushion Melanie T.¹²^ORCID,Ashbaugh Alan¹²,Sayson Steven G.²,Mosley Christopher¹,Hauser Philippe M.³^ORCID

Affiliation:

1. Medical Research Service, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio, USA

2. Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

3. Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

Abstract

The concept of a sexually obligate fungus is unique among human fungal pathogens. This reliance can be exploited for drug development and here we show a proof of principle for this unusual target.

Funder

HHS | National Institutes of Health

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02906-22

Reference23 articles.

1. Echinocandin Treatment of Pneumocystis Pneumonia in Rodent Models Depletes Cysts Leaving Trophic Burdens That Cannot Transmit the Infection

2. Functional and Expression Analyses of the Pneumocystis MAT Genes Suggest Obligate Sexuality through Primary Homothallism within Host Lungs

3. Expression and Immunostaining Analyses Suggest that Pneumocystis Primary Homothallism Involves Trophic Cells Displaying Both Plus and Minus Pheromone Receptors

4. Pneumocystis Mating-Type Locus and Sexual Cycle during Infection

5. Taxonomy, genetic organization, and life cycle of Pneumocystis carinii;Cushion MT;Semin Respir Infect,1998

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