Detection and Characterization of Two Phenotypes of Candida parapsilosis in South Korea: Clinical Features and Microbiological Findings-Reference-Cited by-同舟云学术

Detection and Characterization of Two Phenotypes of Candida parapsilosis in South Korea: Clinical Features and Microbiological Findings

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Byun Jung-Hyun¹,Won Eun Jeong²³,Cho Hae Weon⁴⁵,Kim Daewon⁴,Lee Hyukmin⁴,Kim Soo Hyun²,Choi Min Ji²,Byun Seung A.²,Lee Ga Yeong²,Kee Seung-Jung²,Kim Tae Yeul⁶,Kim Mi-Na³^ORCID,Choi Jun Yong⁷^ORCID,Yong Dongeun⁴,Shin Jong Hee²^ORCID

Affiliation:

1. Department of Laboratory Medicine, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, South Korea

2. Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, South Korea

3. Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

4. Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South Korea

5. Department of Laboratory Medicine, Myongji Hospital, Goyang, South Korea

6. Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

7. Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea

Abstract

We believe that this is the first study describe the microbiological and molecular characteristics of bloodstream isolates of C. parapsilosis in Korea exhibiting two phenotypes (sinking and floating). An important aspect of our findings is that the sinking phenotype was observed predominantly in isolates harboring a Y132F substitution in the ERG11 gene (92.9%), fluconazole-nonsusceptible (FNS) isolates (86.7%), and clonal BSI isolates (74.4%) of C. parapsilosis .

Funder

National Research Foundation of South Korea

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00066-23

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4. Fluconazole‐resistant Candida parapsilosis strains with a Y132F substitution in the ERG11 gene causing invasive infections in a neonatal unit, South Africa

5. Prevalence and Clonal Distribution of Azole-Resistant Candida parapsilosis Isolates Causing Bloodstream Infections in a Large Italian Hospital