Bacteriophage Therapy for the Prevention and Treatment of Fracture-Related Infection Caused by Staphylococcus aureus: a Preclinical Study-Reference-Cited by-同舟云学术

Bacteriophage Therapy for the Prevention and Treatment of Fracture-Related Infection Caused by Staphylococcus aureus: a Preclinical Study

Published:2021-12-22 Issue:3 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Onsea Jolien¹²^ORCID,Post Virginia³,Buchholz Tim³,Schwegler Hella³,Zeiter Stephan³^ORCID,Wagemans Jeroen⁴^ORCID,Pirnay Jean-Paul⁵^ORCID,Merabishvili Maya⁵,D’Este Matteo³^ORCID,Rotman Stijn G.³^ORCID,Trampuz Andrej⁶^ORCID,Verhofstad Michael H. J.⁷^ORCID,Obremskey William T.⁸^ORCID,Lavigne Rob⁴^ORCID,Richards R. Geoff³^ORCID,Moriarty T. Fintan³^ORCID,Metsemakers Willem-Jan¹²^ORCID

Affiliation:

1. Department of Trauma Surgery, University Hospitals Leuven, Leuven, Belgium

2. Department of Development and Regeneration, KU Leuven, Leuven, Belgium

3. AO Research Institute Davos, Davos, Switzerland

4. Laboratory of Gene Technology, KU Leuven, Leuven, Belgium

5. Laboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium

6. Center for Musculoskeletal Surgery, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

7. Trauma Research Unit Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands

8. Department of Orthopaedic Surgery and Rehabilitation, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Abstract

Because of the growing spread of antimicrobial resistance, the use of alternative prevention and treatment strategies is gaining interest. Although the therapeutic potential of bacteriophages has been demonstrated in a number of case reports and series over the past decade, many unanswered questions remain regarding the optimal application protocol.

Funder

AO Trauma Technical Commission

Fonds Wetenschappelijk Onderzoek

Onderzoeksraad, KU Leuven

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01736-21

Reference52 articles.

1. Biomaterial-Associated Infection: A Perspective from the Clinic